Synthesis of α,β-Disubstituted Acrylates via Galat Reaction

Org Lett. 2019 Aug 2;21(15):6135-6139. doi: 10.1021/acs.orglett.9b02291. Epub 2019 Jul 16.

Abstract

Galat reactions between aldehydes and substituted malonic acids half oxyester were found to be efficiently catalyzed by morpholine in refluxing toluene. This transformation allows the stereoselective synthesis of diverse α,β-disubstituted acrylates in moderate to good yields. This method constitutes an attractive alternative to existing methods in terms of scope and eco-compatibility.

Publication types

  • Research Support, Non-U.S. Gov't