The Inflammasome: More Than a Protective Innate Immune Mechanism

Bilyana Stoilova; Paresh Vyas

doi:10.1016/j.immuni.2019.06.022

The Inflammasome: More Than a Protective Innate Immune Mechanism

Immunity. 2019 Jul 16;51(1):3-5. doi: 10.1016/j.immuni.2019.06.022.

Authors

Bilyana Stoilova¹, Paresh Vyas²

Affiliations

¹ MRC MHU, BRC Haematology Theme, Oxford Biomedical Research Centre, Oxford Centre for Haematology, WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
² MRC MHU, BRC Haematology Theme, Oxford Biomedical Research Centre, Oxford Centre for Haematology, WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK. Electronic address: paresh.vyas@imm.ox.ac.uk.

PMID: 31315035
DOI: 10.1016/j.immuni.2019.06.022

Abstract

Little is known about the inflammasome beyond its function in innate immune response. In this issue of Immunity, Tyrkalska et al. report that the inflammasome regulates the balance between erythroid and myeloid differentiation in model systems, providing insights into hematopoietic lineage bias associated with inflammatory conditions.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

GATA1 Transcription Factor*
Hematopoiesis
Immunity, Innate
Inflammasomes*
NLR Family, Pyrin Domain-Containing 3 Protein

Substances

GATA1 Transcription Factor
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein

Abstract

Publication types

MeSH terms

Substances

Grants and funding