NVN1000, a novel nitric oxide-releasing compound, inhibits HPV-18 virus production by interfering with E6 and E7 oncoprotein functions

Antiviral Res. 2019 Oct:170:104559. doi: 10.1016/j.antiviral.2019.104559. Epub 2019 Jul 15.

Authors

N Sanjib Banerjee¹, Dianne W Moore², Hsu-Kun Wang², Thomas R Broker², Louise T Chow²

Affiliations

¹ Biochemistry and Molecular Genetics, University of Alabama at Birmingham, AL, 35294-0005, USA. Electronic address: banerjee@uab.edu.
² Biochemistry and Molecular Genetics, University of Alabama at Birmingham, AL, 35294-0005, USA.

PMID: 31319090
DOI: 10.1016/j.antiviral.2019.104559

No abstract available

Keywords: E6 and E7 functions; Epithelial raft Cultures; HPV DNA amplification; Nitric oxide; Primary human keratinocytes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / pharmacology*
Cells, Cultured
Clinical Trials, Phase II as Topic
DNA Replication
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Foreskin / cytology
Human papillomavirus 18 / drug effects*
Human papillomavirus 18 / genetics
Human papillomavirus 18 / physiology
Humans
Keratinocytes / drug effects
Keratinocytes / virology
Male
Nitric Oxide / metabolism*
Oncogene Proteins, Viral / genetics
Oncogene Proteins, Viral / metabolism*
Papillomavirus E7 Proteins / genetics
Papillomavirus E7 Proteins / metabolism*
Siloxanes / pharmacology*
Virus Replication

Substances

Antiviral Agents
DNA-Binding Proteins
E6 protein, Human papillomavirus type 18
Oncogene Proteins, Viral
Papillomavirus E7 Proteins
Siloxanes
Nitric Oxide
berdazimer sodium