Myths and Misconceptions: Varicella-Zoster Virus Exposure, Infection Risks, Complications, and Treatments

Clin Ther. 2019 Sep;41(9):1816-1822. doi: 10.1016/j.clinthera.2019.06.009. Epub 2019 Jul 17.

Abstract

Varicella zoster and herpes zoster are infections caused by the highly contagious varicella-zoster virus (VZV). Despite widespread availability of vaccines against VZV, as well as varicella vaccination rates >95%, VZV remains a public health concern because of several common myths and misconceptions. Because of the success of routine varicella vaccination programs, some people mistakenly believe that varicella and herpes zoster are now no longer a threat to public health. Another common misconception is that shingles is less infectious than varicella; however, clinical evidence indicates otherwise. Several knowledge gaps exist around VZV transmission and the availability and use of varicella zoster immune globulin (human) for postexposure prophylaxis against VZV. To help reduce the incidence of severe disease in high-risk individuals (eg, elderly people, pregnant women, unvaccinated persons, infants, and immunocompromised children and adults), this article addresses misbeliefs and broadens awareness of VZV exposure, infection risks, complications, and treatments.

Keywords: herpes zoster; postexposure prophylaxis; public health; varicella.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • Environmental Exposure
  • Herpesvirus 3, Human*
  • Humans
  • Immunoglobulins / therapeutic use
  • Post-Exposure Prophylaxis
  • Risk
  • Vaccination
  • Varicella Zoster Virus Infection* / complications
  • Varicella Zoster Virus Infection* / drug therapy
  • Varicella Zoster Virus Infection* / prevention & control
  • Varicella Zoster Virus Infection* / transmission

Substances

  • Antiviral Agents
  • Immunoglobulins