Screening Properties of the Diagnostic Criteria for Cancer-Related Fatigue

Oncol Res Treat. 2019;42(9):440-447. doi: 10.1159/000501128. Epub 2019 Jul 23.

Abstract

Background: Within the theoretical framework of the ICD diagnostic criteria of cancer-related fatigue, we aim to investigate how those criteria can be used for screening purposes.

Methods: Fatigue was assessed in a mixed sample of 1,225 cancer patients during their stay in a rehabilitation clinic using four different fatigue measures and the diagnostic criteria (Criterion A; DC-A). Psychometric evaluations (e.g., acceptance, reliability, validity, item analyses) were conducted for the sum score and for all items of the diagnostic criteria.

Results: A total of 678 (57.1%) patients tested positive according to the DC-A. The sum score of the DC-A had good reliability (Cronbach's alpha = 0.87) and validity, corresponded closely with other fatigue scales, and, with less than 1% missing values, showed a high degree of patients' acceptance. The highest accuracy (approx. 0.80) and Youden indices (>0.55) were found for the items "Difficulties completing daily tasks" (A9), "Struggle to overcome inactivity" (A7), "Decreased motivation or interests" (A4), and "Unrefreshing sleep" (A6).

Conclusion: The DC-A proved to be a well-accepted, easy to use, and reliable tool for measuring the severity of fatigue. In this paper, we make suggestions for the use of single items of the DC-A as a short and economical screening tool.

Keywords: Assessment; Cancer-related fatigue; Diagnosis; Psychometric properties.

Publication types

  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Fatigue / diagnosis*
  • Fatigue / etiology*
  • Female
  • Germany
  • Humans
  • Male
  • Mass Screening / methods*
  • Middle Aged
  • Neoplasms / complications*
  • Neoplasms / rehabilitation
  • Psychometrics / methods
  • Rehabilitation Centers
  • Reproducibility of Results
  • Surveys and Questionnaires
  • Young Adult