The accuracy of transcutaneous bilirubinometry in preterm infants

J Perinatol. 2020 Feb;40(2):212-218. doi: 10.1038/s41372-019-0445-3. Epub 2019 Jul 30.

Abstract

Objective: To evaluate the correlation between total serum and transcutaneous bilirubin and to determine the reliability of transcutaneous bilirubinometry for screening and monitoring of neonatal jaundice among preterms.

Study design: Ninety nine infants with gestational ages ≤34 weeks were prospectively enrolled. Babies were classified into three groups as; 24-28, 29-31, and 32-34 weeks. Total serum bilirubin and simultaneous transcutaneous bilirubin were measured before the onset of phototheraphy, during and at 24 h after discontinuing phototherapy.

Results: Total serum bilirubin significantly correlated with transcutaneous bilirubin in the whole cohort (r = 0.867, p < 0.001) and in each group before, during and after phototheraphy. Hypotension was the only variable which effects the difference between two methods at postnatal first day of life (p = 0.039).

Conclusion: Transcutaneous bilirubin levels were highly correlated with total serum bilirubin levels even in 24-28 GW babies. Transcutaneous bilirubin may be useful for screening and monitoring of jaundice in very preterm newborns.

Publication types

  • Observational Study
  • Validation Study

MeSH terms

  • Bilirubin / blood*
  • Blood Chemical Analysis / methods*
  • Female
  • Gestational Age
  • Humans
  • Infant, Extremely Premature / blood
  • Infant, Newborn
  • Infant, Premature / blood*
  • Infant, Premature, Diseases / blood*
  • Infant, Premature, Diseases / diagnosis
  • Jaundice, Neonatal / blood*
  • Jaundice, Neonatal / diagnosis
  • Male
  • Neonatal Screening / methods
  • Prospective Studies
  • Reproducibility of Results

Substances

  • Bilirubin