Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy

Blood Adv. 2019 Aug 13;3(15):2317-2322. doi: 10.1182/bloodadvances.2019000219.

Abstract

  1. Reexpansion of CAR T cells led to further investigations which confirmed the clonal nature of this expansion.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Culture Techniques*
  • Female
  • Gene Expression*
  • Genetic Vectors / genetics
  • Humans
  • Immunotherapy, Adoptive* / methods
  • Lentivirus / genetics
  • Positron-Emission Tomography
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Proto-Oncogene Proteins c-cbl / genetics*
  • Proto-Oncogene Proteins c-cbl / metabolism
  • Sialic Acid Binding Ig-like Lectin 2 / antagonists & inhibitors*
  • Sialic Acid Binding Ig-like Lectin 2 / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*
  • Transduction, Genetic
  • Transgenes
  • Treatment Outcome

Substances

  • Sialic Acid Binding Ig-like Lectin 2
  • Proto-Oncogene Proteins c-cbl
  • CBL protein, human