Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

Physiology (Bethesda). 2019 Sep 1;34(5):365-375. doi: 10.1152/physiol.00005.2019.

Abstract

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. We review here how brain organoids have been used to study neurodevelopmental disease and consider their potential for both technological advancement and therapeutic development.

Keywords: disease modeling; neurodevelopmental disease; organoids; stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiopathology*
  • Humans
  • Models, Biological
  • Neurodevelopmental Disorders / physiopathology*
  • Organoids / physiopathology*