IgM binding to sialosyllactosaminylparagloboside in a patient with polyradiculoneuropathy due to Mycoplasma pneumoniae infection

Acta Neurol Scand. 1988 Jul;78(1):53-7. doi: 10.1111/j.1600-0404.1988.tb03619.x.

Abstract

IgM in serum without paraprotein in a patient with polyradiculoneuropathy due to a Mycoplasma pneumoniae infection reacted specifically with a ganglioside, sialosyllactosaminylparagroboside (SLPG), in a human peripheral nerve on a thin-layer chromatogram plate by an immunostaining technique. This finding suggests the possibility that anti-SLPG antibody in the patient's serum may play a role in the pathogenesis of neuropathy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Gangliosides / metabolism
  • Globosides / metabolism*
  • Glycosphingolipids / metabolism*
  • Humans
  • Immunoglobulin mu-Chains / blood*
  • Middle Aged
  • Pneumonia, Mycoplasma / complications*
  • Polyradiculoneuropathy / etiology
  • Polyradiculoneuropathy / immunology*
  • Polyradiculoneuropathy / microbiology

Substances

  • Gangliosides
  • Globosides
  • Glycosphingolipids
  • Immunoglobulin mu-Chains
  • sialosyllactosaminylparagloboside