Effects of Omega-3 Supplementation on Exploratory Outcomes in the Dry Eye Assessment and Management Study

Marko Oydanich; Maureen G Maguire; Maxwell Pistilli; Pedram Hamrah; Jack V Greiner; Meng C Lin; Penny A Asbell; Dry Eye Assessment and Management Study Research Group

doi:10.1016/j.ophtha.2019.07.009

Effects of Omega-3 Supplementation on Exploratory Outcomes in the Dry Eye Assessment and Management Study

Ophthalmology. 2020 Jan;127(1):136-138. doi: 10.1016/j.ophtha.2019.07.009. Epub 2019 Jul 25.

Authors

Marko Oydanich¹, Maureen G Maguire², Maxwell Pistilli³, Pedram Hamrah⁴, Jack V Greiner⁵, Meng C Lin⁶, Penny A Asbell⁷; Dry Eye Assessment and Management Study Research Group

Affiliations

¹ Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, New Jersey.
² Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: maguirem@pennmedicine.upenn.edu.
³ Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.
⁴ Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
⁵ Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
⁶ Clinical Research Center, Berkeley Optometry, University of California, Berkeley, Berkeley, California.
⁷ Hamilton Eye Institute, University of Tennessee Health Science Center (UTHSC), Memphis Tennessee.

Abstract

We report results from a multicenter, randomized clinical trial (N=535) of the effect of ω-3 supplementation, relative to placebo, on exploratory and minimally invasive outcome measures for moderate to severe dry eye disease.

Publication types

Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

MeSH terms

Docosahexaenoic Acids / administration & dosage
Double-Blind Method
Dry Eye Syndromes / drug therapy*
Dry Eye Syndromes / metabolism
Eicosapentaenoic Acid / administration & dosage
Fatty Acids, Omega-3 / administration & dosage*
Fluorophotometry
Humans
Lipid Metabolism
Matrix Metalloproteinase 9 / metabolism
Osmolar Concentration
Tears / chemistry
Tears / physiology
Treatment Outcome

Substances

Fatty Acids, Omega-3
Docosahexaenoic Acids
Eicosapentaenoic Acid
MMP9 protein, human
Matrix Metalloproteinase 9

Abstract

Publication types

MeSH terms

Substances

Grants and funding