Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease

Aging (Albany NY). 2019 Aug 27;11(16):5871-5873. doi: 10.18632/aging.102210. Epub 2019 Aug 27.

Authors

Nikhil Panicker^{1

2}, Arthi Kanthasamy³, Anumantha G Kanthasamy³

Affiliations

¹ Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
³ Parkinson Disorders Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

No abstract available

Keywords: Fyn; aging; brain inflammation; inflammasome; neurodegenerative diseases.

Publication types

Editorial

MeSH terms

Animals
Humans
Inflammasomes / metabolism*
Microglia / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism*
Parkinson Disease / metabolism*
Proto-Oncogene Proteins c-fyn / metabolism*
Signal Transduction / physiology*

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Proto-Oncogene Proteins c-fyn

Grants and funding