Disseminated lymphoblastic lymphoma revealed by an isolated third cranial nerve palsy

Eur J Ophthalmol. 2021 Mar;31(2):NP131-NP135. doi: 10.1177/1120672119873275. Epub 2019 Sep 3.

Abstract

Dysfunction of the third cranial nerve can be provoked by a number of different conditions. An isolated cranial neuropathy as a first clinical sign of a non-Hodgkin lymphoma is very infrequent. We represent here an atypical case of lymphoblastic lymphoma revealed by an isolated third cranial nerve palsy. The patient was managed by alternating cycles of cyclophosphamide, vincristine, and prednisone. She made a full recovery with a complete resolution of the symptomatology.

Keywords: Ptosis; lymphoma; third cranial nerve palsy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Blepharoptosis / diagnosis*
  • Blepharoptosis / drug therapy
  • Blepharoptosis / pathology
  • Cyclophosphamide / therapeutic use
  • Female
  • Fluorescein Angiography
  • Humans
  • Magnetic Resonance Imaging
  • Myelopoiesis
  • Oculomotor Nerve Diseases / diagnosis*
  • Oculomotor Nerve Diseases / drug therapy
  • Oculomotor Nerve Diseases / pathology
  • Ophthalmoplegia / diagnosis*
  • Ophthalmoplegia / drug therapy
  • Ophthalmoplegia / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prednisone / therapeutic use
  • Thrombopoiesis
  • Tomography, Optical Coherence
  • Vincristine / therapeutic use
  • Visual Acuity

Substances

  • Vincristine
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • COP protocol 2