Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling

Sheila S Rajagopalan; Andrew M Miller; Coralie de Hemptinne; Marta San Luciano; Jill L Ostrem; Philip A Starr

doi:10.1016/j.parkreldis.2019.08.018

Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling

Parkinsonism Relat Disord. 2019 Sep:66:269-271. doi: 10.1016/j.parkreldis.2019.08.018. Epub 2019 Aug 27.

Authors

Sheila S Rajagopalan¹, Andrew M Miller², Coralie de Hemptinne³, Marta San Luciano⁴, Jill L Ostrem⁵, Philip A Starr⁶

Affiliations

¹ Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: Sheila.Rajagopalan@ucsf.edu.
² Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA; School of Medicine, University of Kansas, Kansas City, KS, USA. Electronic address: Amiller36@kumc.edu.
³ Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: Coralie.deHemptinne@ucsf.edu.
⁴ Department of Neurology, University of California San Francisco, San Francisco, CA, USA. Electronic address: Marta.Sanluciano@ucsf.edu.
⁵ Department of Neurology, University of California San Francisco, San Francisco, CA, USA. Electronic address: Jill.Ostrem@ucsf.edu.
⁶ Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA; Parkinson's Disease Research, Education and Clinical Center at the San Francisco Veteran's Affairs Medical Center, San Francisco, CA, USA; Graduate Program in Neuroscience, University of California, San Francisco, CA, USA. Electronic address: Philip.Starr@ucsf.edu.

Abstract

Invasive human brain recordings have shown that acute therapeutic deep brain stimulation (DBS) reduces cortical synchronization, measured by coupling of beta phase to gamma amplitude. Here we show by noninvasive scalp electroencephalography that withdrawal of chronic DBS elevates phase-amplitude coupling, in proportion to the worsening of contralateral rigidity.

Keywords: Deep brain stimulation; Electroencephalography; Parkinson's disease; Phase-amplitude coupling.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Brain Waves / physiology*
Cerebral Cortex / physiopathology*
Cortical Synchronization / physiology*
Deep Brain Stimulation*
Humans
Middle Aged
Muscle Rigidity* / etiology
Muscle Rigidity* / physiopathology
Muscle Rigidity* / therapy
Parkinson Disease* / complications
Parkinson Disease* / physiopathology
Parkinson Disease* / therapy

Abstract

Publication types

MeSH terms

Grants and funding