Extradural Compressive Spinal Cerebrospinal Fluid Leak in Ehlers-Danlos Syndrome

Laura Pradini-Santos; Claudia L Craven; Parag P Sayal

doi:10.1016/j.wneu.2019.08.163

Extradural Compressive Spinal Cerebrospinal Fluid Leak in Ehlers-Danlos Syndrome

World Neurosurg. 2019 Dec:132:67-68. doi: 10.1016/j.wneu.2019.08.163. Epub 2019 Aug 31.

Authors

Laura Pradini-Santos¹, Claudia L Craven², Parag P Sayal¹

Affiliations

¹ Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, England.
² Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, England. Electronic address: claudia.craven@gmail.com.

PMID: 31479794
DOI: 10.1016/j.wneu.2019.08.163

Abstract

Ehlers-Danlos syndrome can be associated with cerebrospinal fluid (CSF) disturbances including recurrent CSF leak and Chiari I malformations. Persistent pseudomeningoceles are known to be associated with raised intracranial pressure. We present an unusual case of a compressive epidural CSF collection occurring after a computed tomography-guided L5 nerve root block and describe an effective management strategy.

Keywords: Cerebrospinal fluid; Connective tissue disorder; Epidural injection; Spine.

Publication types

Case Reports

MeSH terms

Adult
Arnold-Chiari Malformation / complications
Cerebrospinal Fluid Leak / diagnostic imaging
Cerebrospinal Fluid Leak / etiology*
Cerebrospinal Fluid Leak / surgery
Ehlers-Danlos Syndrome / complications*
Female
Humans
Injections, Epidural / adverse effects*
Intracranial Hypertension / complications*
Lumbar Vertebrae
Nerve Block
Radiculopathy / drug therapy
Radiculopathy / etiology
Spinal Cord Compression / diagnostic imaging
Spinal Cord Compression / etiology*
Spinal Cord Compression / surgery
Spondylolisthesis / complications
Tomography, X-Ray Computed

Supplementary concepts

Ehlers-Danlos syndrome type 3