In vivo leukocyte chemotaxis during the development of acute experimental Trypanosoma cruzi infection

F G Abath; S M Montenegro; A B Carvalho

In vivo leukocyte chemotaxis during the development of acute experimental Trypanosoma cruzi infection

Braz J Med Biol Res. 1988;21(5):1013-4.

Authors

F G Abath¹, S M Montenegro, A B Carvalho

Affiliation

¹ Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Recife, Brasil.

PMID: 3150293

Abstract

Five and 15 days after T. cruzi infection, staphylococcal protein A was injected into a connective tissue air pouch of mice and the migration of polymorphonuclear leukocytes into the area was monitored. The PMN leukocyte response of 15-day infected mice was lower than that of uninfected mice (P less than 0.001): The 15-day infected mice also showed a lower PMN leukocyte response when compared to 5-day infected mice (P less than 0.001). These data suggest that the chemotaxis defect developed gradually during the acute phase of infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chagas Disease / immunology*
Chemotaxis, Leukocyte* / drug effects
Mice
Mice, Inbred BALB C
Neutrophils / physiology
Staphylococcal Protein A / pharmacology

Substances

Staphylococcal Protein A