Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function

Santiago Nahuel Villegas; Dolors Ferres-Marco; María Domínguez

doi:10.1007/978-3-030-23629-8_2

Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function

Adv Exp Med Biol. 2019:1167:15-35. doi: 10.1007/978-3-030-23629-8_2.

Authors

Santiago Nahuel Villegas¹, Dolors Ferres-Marco², María Domínguez³

Affiliations

¹ Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas (CSIC) and Universidad Miguel Hernández (UMH), Alicante, Spain. svillegas@umh.es.
² Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas (CSIC) and Universidad Miguel Hernández (UMH), Alicante, Spain. dferres@umh.es.
³ Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas (CSIC) and Universidad Miguel Hernández (UMH), Alicante, Spain.

PMID: 31520347
DOI: 10.1007/978-3-030-23629-8_2

Abstract

The formation, overgrowth and metastasis of tumors comprise a complex series of cellular and molecular events resulting from the combined effects of a variety of aberrant signaling pathways, mutations, and epigenetic alterations. Modeling this complexity in vivo requires multiple genes to be manipulated simultaneously, which is technically challenging. Here, we analyze how Drosophila research can further contribute to identifying pathways and elucidating mechanisms underlying novel cancer driver (risk) genes associated with tumor growth and metastasis in humans.

Keywords: Cancer driver genes; Cancer genetic toolkit; Drosophila.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Drosophila*
Humans
Mutation
Neoplasms*
Oncogenes*
Signal Transduction