Leukemic lineage switch in a t(8;22)(p11.2;q11.2)/ BCR-FGFR1-rearranged myeloid/lymphoid neoplasm with RUNX1 mutation - diagnostic pitfalls and clinical management including FGFR1 inhibitor pemigatinib

Leuk Lymphoma. 2020 Feb;61(2):450-454. doi: 10.1080/10428194.2019.1660975. Epub 2019 Sep 16.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Core Binding Factor Alpha 2 Subunit* / genetics
  • Gene Rearrangement
  • Humans
  • Leukemia, Myeloid / drug therapy*
  • Leukemia, Myeloid / genetics*
  • Male
  • Middle Aged
  • Morpholines / therapeutic use*
  • Mutation
  • Pyrimidines / therapeutic use*
  • Pyrroles / therapeutic use*
  • Receptor, Fibroblast Growth Factor, Type 1 / genetics
  • Translocation, Genetic

Substances

  • Core Binding Factor Alpha 2 Subunit
  • Morpholines
  • Pyrimidines
  • Pyrroles
  • RUNX1 protein, human
  • FGFR1 protein, human
  • Receptor, Fibroblast Growth Factor, Type 1
  • pemigatinib