This study assessed whether a focal glove hypnotic hand anesthesia induced thermal changes within the area of hypnotic protection. Skin temperature of hands, wrists, and forearms was continuously recorded bilaterally using infrared thermography in 30 volunteers. Thermal recordings were obtained prior to, after glove building, and after its withdrawal, with the contralateral upper limb serving as control side. Analgesic glove induced a statistically significant difference in temperature variation within the hand, wrist, and distal forearm on the glove side, compared with proximal forearm and control side. Hypnotic glove analgesia provides significant changes in skin temperature within protected areas. Further research is required to determine the mechanisms of these objective changes induced by hypnosis.