Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long-acting activated memory cells induced by nivolumab against malignant melanoma

Katsunori Katagiri; Kiyoto Shiga; Daisuke Saito; Shin-Ichi Oikawa; Aya Ikeda; Kodai Tsuchida; Jun Miyaguchi

doi:10.1002/ccr3.2349

Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long-acting activated memory cells induced by nivolumab against malignant melanoma

Clin Case Rep. 2019 Jul 31;7(9):1709-1713. doi: 10.1002/ccr3.2349. eCollection 2019 Sep.

Authors

Katsunori Katagiri¹, Kiyoto Shiga¹, Daisuke Saito¹, Shin-Ichi Oikawa¹, Aya Ikeda¹, Kodai Tsuchida¹, Jun Miyaguchi¹

Affiliation

¹ Department of Head and Neck Surgery Iwate Medical University Morioka Japan.

Abstract

Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti-PD-1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months.

Keywords: glucocorticoids; interstitial pneumonitis; lung metastasis; mucosal malignant melanoma; nivolumab.

Publication types

Case Reports