Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women

Bani Tamraz; Yong Huang; Audrey L French; Seble Kassaye; Kathryn Anastos; Marek J Nowicki; Stephen Gange; Deborah R Gustafson; Peter Bacchetti; Ruth M Greenblatt; Pirro G Hysi; Bradley E Aouizerat; Women's Interagency HIV Study

doi:10.1002/cpt.1605

Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women

Clin Pharmacol Ther. 2020 Feb;107(2):315-318. doi: 10.1002/cpt.1605. Epub 2019 Sep 28.

Authors

Affiliations

¹ School of Pharmacy, University of California San Francisco, San Francisco, California, USA.
² Infectious Diseases, CORE Center/Stroger Hospital of Cook County, Chicago, Illinois, USA.
³ Department of Medicine, Georgetown University, Washington, DC, USA.
⁴ Departments of Medicine and Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
⁵ Department of Medicine, University of Southern California, Los Angeles, California, USA.
⁶ John Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
⁷ Department of Neurology, State University of New York - Downstate Medical Center, Brooklyn, New York, USA.
⁸ Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California, USA.
⁹ Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
¹⁰ Great Ormand Street Institute for Child Health, University College London, London, UK.
¹¹ Bluestone Center for Clinical Research, College of Dentistry, New York University, New York, New York, USA.

Abstract

SORCS2 rs73208473 was recently associated with decreased atazanavir (ATV) concentration in the hair of women with seropositive HIV. Herein, we report on a pharmacogenetic study of women with seropositive HIV demonstrating a similar association between rs73208473 and dose-adjusted plasma ATV concentration in African Americans.

Publication types

Multicenter Study
Observational Study
Research Support, N.I.H., Extramural

MeSH terms

ATP Binding Cassette Transporter, Subfamily B / genetics
Area Under Curve
Atazanavir Sulfate / administration & dosage
Atazanavir Sulfate / pharmacokinetics*
Chromatography, High Pressure Liquid
Citrus sinensis
Cytochrome P-450 CYP3A Inhibitors / pharmacology
Diarrhea / epidemiology
Dose-Response Relationship, Drug
Female
Genotype
HIV Infections / drug therapy*
HIV Infections / epidemiology
HIV Protease Inhibitors / administration & dosage
HIV Protease Inhibitors / pharmacokinetics*
Hair / chemistry
Heroin Dependence / epidemiology
Humans
Hydrogen-Ion Concentration
Longitudinal Studies
MicroRNAs
Polymorphism, Single Nucleotide
Racial Groups
Receptors, Cell Surface / genetics*
Tandem Mass Spectrometry

Substances

ABCB1 protein, human
ATP Binding Cassette Transporter, Subfamily B
Cytochrome P-450 CYP3A Inhibitors
HIV Protease Inhibitors
MicroRNAs
Receptors, Cell Surface
SORCS2 protein, human
Atazanavir Sulfate

Abstract

Publication types

MeSH terms

Substances

Grants and funding