Pharmacokinetics of Dasatinib

Prague Med Rep. 2019;120(2-3):52-63. doi: 10.14712/23362936.2019.10.

Abstract

Tyrosine kinase inhibitors have recently become an essential tool in management of chronic myeloid leukaemia (CML). Dasatinib, a representative of those drugs, acts by inhibiting key proteins included in CML development, predominantly Bcr-Abl and Src. Its advantage is that it shows activity in many cases where other agents bring no improvement due to resistance. Pharmacokinetics of dasatinib has specific characteristics that may play an important role in achieving sufficient exposure in patients. Therefore, the key pharmacokinetic properties are summarized in this report. For example, dasatinib absorption is significantly influenced by gastric pH and its modulation can be a source of serious interactions, as well as simultaneous administration of drugs affecting cytochrome P450.

Keywords: Dasatinib; Drug interaction; Pharmacokinetics; pH-dependent absorption.

Publication types

  • Review

MeSH terms

  • Cytochrome P-450 Enzyme System
  • Dasatinib / pharmacokinetics*
  • Dasatinib / therapeutic use
  • Drug Resistance, Neoplasm
  • Gastric Acid
  • Humans
  • Hydrogen-Ion Concentration
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
  • Protein Kinase Inhibitors / pharmacokinetics
  • Protein Kinase Inhibitors / therapeutic use

Substances

  • Protein Kinase Inhibitors
  • Cytochrome P-450 Enzyme System
  • Dasatinib