Abstract
The inhibitory effects of various prostaglandins (PGA2, PGD2 and PGE2) on the growth of human gingival carcinoma cell line Ca 9-22 and human cervical carcinoma cell line HeLa were studied in vitro. 1. PGA2 and PGD2 significantly depressed Ca 9-22 cell proliferation in dose and time related fashion. 2. The inhibitory rate by PGs for Ca 9-22 cells exceeded than HeLa-cells. 3. IC50 value of PGD2 on growth of Ca 9-22 was calculated to be 4 micrograms/ml.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Division / drug effects
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Dinoprostone
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Gingival Neoplasms / pathology*
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HeLa Cells
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Humans
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Prostaglandin D2
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Prostaglandins / pharmacology*
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Prostaglandins A / pharmacology
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Prostaglandins D / pharmacology
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Prostaglandins E / pharmacology
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Tumor Cells, Cultured / drug effects*
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Tumor Cells, Cultured / pathology
Substances
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Prostaglandins
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Prostaglandins A
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Prostaglandins D
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Prostaglandins E
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prostaglandin A2
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Dinoprostone
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Prostaglandin D2