Acute myeloid leukaemia presenting as acute liver failure-a case report and literature review

Kai Sun; Ryan J Reynolds; Tiffany G Sheu; Jessica A Tomsula; Lara Colton; Lawrence Rice

doi:10.3332/ecancer.2019.960

Acute myeloid leukaemia presenting as acute liver failure-a case report and literature review

Ecancermedicalscience. 2019 Sep 9:13:960. doi: 10.3332/ecancer.2019.960. eCollection 2019.

Authors

Kai Sun¹, Ryan J Reynolds¹, Tiffany G Sheu², Jessica A Tomsula², Lara Colton^{1

3}, Lawrence Rice^{1

3}

Affiliations

¹ Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
² Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
³ Weill Cornell Medical College, Houston, TX 77030, USA.

Abstract

A 75-year-old woman presented with rapidly progressive fatigue, abdominal pain and jaundice. Physical examination revealed tender abdomen and splenomegaly. Magnetic resonance cholangiogram showed marked hepatomegaly, splenomegaly and scattered nodules or masses in the liver and spleen. The patient expired from multiorgan failure. Autopsy revealed infiltration of the liver, spleen and bone marrow by acute myeloid leukaemia.

Keywords: acute liver failure; acute myeloid leukaemia; obstructive jaundice.

Publication types

Case Reports