Aortic valve stenosis-multimodality assessment with PET/CT and PET/MRI

Br J Radiol. 2020 Sep 1;93(1113):20190688. doi: 10.1259/bjr.20190688. Epub 2019 Nov 1.

Abstract

Aortic valve disease is the most common form of heart valve disease in developed countries and a growing healthcare burden with an ageing population. Transthoracic and transoesophageal echocardiography remains central to the diagnosis and surveillance of patients with aortic stenosis, providing gold standard assessments of valve haemodynamics and myocardial performance. However, other multimodality imaging techniques are being explored for the assessment of aortic stenosis, including combined PET/CT and PET/MR. Both approaches provide unique information with respect to disease activity in the valve alongside more conventional anatomic assessments of the valve and myocardium in this condition. This review investigates the emerging use of PET/CT and PET/MR to assess patients with aortic stenosis, examining how the complementary data provided by each modality may be used for research applications and potentially in future clinical practice.

Publication types

  • Review

MeSH terms

  • Aortic Valve / diagnostic imaging
  • Aortic Valve / metabolism
  • Aortic Valve Stenosis / diagnostic imaging*
  • Aortic Valve Stenosis / metabolism
  • Disease Progression
  • Fluorine Radioisotopes / pharmacokinetics
  • Fluorodeoxyglucose F18 / pharmacokinetics
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Multimodal Imaging / methods*
  • Positron Emission Tomography Computed Tomography / methods
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals / pharmacokinetics
  • Tomography, X-Ray Computed / methods*
  • Vascular Calcification / diagnostic imaging

Substances

  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Fluorine-18