Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia

Biochim Biophys Acta. 1988 Oct 14;962(3):387-9. doi: 10.1016/0005-2760(88)90270-6.

Abstract

Acetylated low-density lipoprotein (acetyl-LDL) stimulated the incorporation of [14C]oleate into cholesteryl [14C]oleate in peritoneal macrophages from both normal and Watanabe heritable hyperlipidemic (WHHL) rabbits. A degradation study showed that macrophages from WHHL rabbits degraded the same amount of 125I-labeled acetyl-LDL as macrophages from normal rabbits. These findings indicate that macrophages of WHHL rabbits have functional acetyl-LDL receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ascitic Fluid / cytology
  • Cell Adhesion Molecules*
  • Cells, Cultured
  • Cholesterol Esters / biosynthesis
  • Disease Models, Animal*
  • Hyperlipidemias / genetics*
  • Hyperlipidemias / metabolism
  • Hyperlipoproteinemia Type II*
  • Lipoproteins, LDL / metabolism*
  • Macrophages / metabolism*
  • Rabbits
  • Receptors, LDL / metabolism
  • Receptors, Scavenger

Substances

  • Cell Adhesion Molecules
  • Cholesterol Esters
  • Lipoproteins, LDL
  • Receptors, LDL
  • Receptors, Scavenger
  • acetyl-LDL
  • cholesteryl oleate