Activity of Aerosolized Levofloxacin against Burkholderia cepacia in a Mouse Model of Chronic Lung Infection

Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01988-19. doi: 10.1128/AAC.01988-19. Print 2020 Jan 27.

Abstract

Burkholderia cepacia complex is an opportunistic pathogen capable of causing chronic pulmonary infections. These studies were conducted to demonstrate the activity of aerosolized levofloxacin in a chronic mouse lung infection model caused by B. cepacia isolates from patients with cystic fibrosis. Treatment with aerosolized levofloxacin for 4 days produced at least 1 log CFU of bacterial killing against all strains tested, suggesting possible utility in the treatment of lung infections caused by B. cepacia isolates.

Keywords: B. cepacia; aerosolized levofloxacin; mouse lung infection.

MeSH terms

  • Administration, Inhalation
  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Burkholderia Infections / complications
  • Burkholderia Infections / drug therapy*
  • Burkholderia Infections / microbiology
  • Burkholderia cepacia complex / drug effects*
  • Chronic Disease
  • Cystic Fibrosis / complications*
  • Female
  • Humans
  • Levofloxacin / administration & dosage*
  • Lung / microbiology
  • Mice
  • Mice, Inbred BALB C
  • Respiratory Tract Infections / complications
  • Respiratory Tract Infections / drug therapy*
  • Respiratory Tract Infections / microbiology

Substances

  • Anti-Bacterial Agents
  • Levofloxacin