Stressing Out about Cancer Immunotherapy

Xue-Yan He; David Ng; Linda Van Aelst; Mikala Egeblad

doi:10.1016/j.ccell.2019.10.013

Stressing Out about Cancer Immunotherapy

Cancer Cell. 2019 Nov 11;36(5):468-470. doi: 10.1016/j.ccell.2019.10.013.

Authors

Xue-Yan He¹, David Ng¹, Linda Van Aelst¹, Mikala Egeblad²

Affiliations

¹ Cold Spring Harbor Laboratory, Cancer Center, Cold Spring Harbor, NY 11724, USA.
² Cold Spring Harbor Laboratory, Cancer Center, Cold Spring Harbor, NY 11724, USA. Electronic address: egeblad@cshl.edu.

PMID: 31715130
DOI: 10.1016/j.ccell.2019.10.013

Abstract

Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells-the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3-as a potent, immunosuppressive effect of stress on cancer.

Publication types

Review

MeSH terms

Dendritic Cells / immunology*
Dendritic Cells / metabolism
Disease Progression
Glucocorticoids / immunology
Glucocorticoids / metabolism*
Humans
Immune Tolerance
Immunotherapy*
Neoplasms / immunology
Neoplasms / mortality
Neoplasms / psychology
Neoplasms / therapy*
Stress, Psychological / immunology*
Stress, Psychological / psychology
Transcription Factors / immunology
Transcription Factors / metabolism
Treatment Outcome

Substances

Glucocorticoids
TSC22D3 protein, human
Transcription Factors