Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD

J Neuroimmunol. 2020 Jan 15:338:577110. doi: 10.1016/j.jneuroim.2019.577110. Epub 2019 Nov 6.

Abstract

Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients with MOG-IgG associated disorders, multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (NMOSD). A total of 102 serum samples were retrospectively analyzed. Antibody reactivity against HERV-W env peptides was similar in MOG-IgG associated disorders and MS, but different from AQP4-IgG positive NMOSD. Our findings expand the diagnostic role of HERV-W antibodies to the spectrum of demyelinating disorders associated with MOG-IgG.

Keywords: Autoimmunity; Human endogenous retroviruses; MS; Myelin oligodendrocyte glycoprotein; Neuromyelitis optica spectrum disorder.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aquaporin 4 / immunology
  • Autoantibodies / blood*
  • Female
  • Gene Products, env / immunology*
  • Humans
  • Immunoglobulin G / blood*
  • Male
  • Middle Aged
  • Multiple Sclerosis / immunology*
  • Myelin-Oligodendrocyte Glycoprotein / immunology*
  • Neuromyelitis Optica / immunology*
  • Pregnancy Proteins / immunology*
  • Retrospective Studies

Substances

  • AQP4 protein, human
  • Aquaporin 4
  • Autoantibodies
  • Gene Products, env
  • Immunoglobulin G
  • Myelin-Oligodendrocyte Glycoprotein
  • Pregnancy Proteins
  • syncytin