Clozapine Induced Neuroleptic Malignant Syndrome

Yong Suk Jo; Hyung Ah Jo; Byung Chul Yu; Jung Hoon Shin; Kook-Hwan Oh

doi:10.4266/kjccm.2016.00052

Clozapine Induced Neuroleptic Malignant Syndrome

Korean J Crit Care Med. 2017 Aug;32(3):291-294. doi: 10.4266/kjccm.2016.00052. Epub 2016 Dec 29.

Authors

Yong Suk Jo¹, Hyung Ah Jo², Byung Chul Yu², Jung Hoon Shin³, Kook-Hwan Oh²

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
² Division of Nephrology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
³ Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Neuroleptic malignant syndrome is a rare, but potentially life-threatening adverse event associated with the use of neuroleptic agents. We describe the case of a 47-year-old schizophrenic woman who was treated with clozapine for years. The patient developed acute renal failure with pulmonary edema, and underwent mechanical ventilation and hemodialysis.

Keywords: acute kidney injury; clozapine; neuroleptic malignant syndrome; rhabdomyolysis.

Publication types

Case Reports