miRNA-Microbiota Interaction in Gut Homeostasis and Colorectal Cancer

Jiayi Dong; Jesse W Tai; Li-Fan Lu

doi:10.1016/j.trecan.2019.08.003

miRNA-Microbiota Interaction in Gut Homeostasis and Colorectal Cancer

Trends Cancer. 2019 Nov;5(11):666-669. doi: 10.1016/j.trecan.2019.08.003. Epub 2019 Oct 14.

Authors

Jiayi Dong¹, Jesse W Tai¹, Li-Fan Lu²

Affiliations

¹ Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
² Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: lifanlu@ucsd.edu.

Abstract

Gut homeostasis is maintained by dynamic host-microbiota interactions. Recently, miRNAs have emerged as key molecular regulators in the mediation of such interactions. Here, we discuss the role of a host miRNA-microbiome axis in gut homeostasis and colorectal cancer (CRC) and the involvement of diet and microbial metabolites in miRNA-mediated intestinal health.

Keywords: colorectal cancer; diet; miRNA; microbiome.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Colorectal Neoplasms / genetics*
Colorectal Neoplasms / microbiology*
Diet
Gastrointestinal Microbiome / genetics*
Homeostasis
Humans
MicroRNAs*

Substances

MicroRNAs

Grants and funding

R01 AI108651/AI/NIAID NIH HHS/United States