Retinal and Choroidal Perfusion Status in the Area of Laser Scars Assessed With Swept-Source Optical Coherence Tomography Angiography

Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4865-4871. doi: 10.1167/iovs.19-27977.

Abstract

Purpose: To evaluate the perfusion status of the retina and choriocapillaris in the area of laser scars on swept-source optical coherence tomography angiography (OCTA) images of eyes previously treated with panretinal photocoagulation (PRP).

Methods: Cross-sectional exploratory analysis of swept-source OCTA images, which were retrospectively reviewed for laser scars. The appearance of the capillary networks in the area of previous laser were evaluated following a three-step grading system (normal/sparse/missing capillary network). The superficial and deep capillary plexus of the retina and the choriocapillaris were graded separately.

Results: A total of 3140 laser scars in 54 eyes of 31 patients (13 female, mean age 57 ± 12 years) were included in this analysis. In the retina, 6.8% of the superficial and deep capillary network in the area evaluated appeared normal, 58% and 56% sparse, and 35% and 37% missing. Capillary dropout in the retina was not restricted to the area of prior laser treatment. The choriocapillaris decorrelation signal was either sparse (61%) or completely missing (38%) within the laser scar area. The perfusion of the choriocapillaris appeared normal in the area adjacent to laser scars.

Conclusions: Capillary non-perfusion in the choriocapillaris was found within the laser scar area. Laser treatment seems to cause sustained non-perfusion of choriocapillaris in the area treated.

MeSH terms

  • Aged
  • Capillaries / physiology
  • Choroid / blood supply*
  • Cicatrix / diagnosis
  • Cicatrix / physiopathology*
  • Cross-Sectional Studies
  • Diabetic Retinopathy / diagnosis
  • Diabetic Retinopathy / physiopathology*
  • Diabetic Retinopathy / surgery
  • Female
  • Fluorescein Angiography / methods
  • Humans
  • Laser Coagulation*
  • Male
  • Middle Aged
  • Regional Blood Flow / physiology
  • Retinal Vessels / physiology*
  • Retrospective Studies
  • Tomography, Optical Coherence / methods