The Brain Epigenome Goes Drunk: Alcohol Consumption Alters Histone Acetylation and Transcriptome

Irene de Diego; Annika Müller-Eigner; Shahaf Peleg

doi:10.1016/j.tibs.2019.11.002

The Brain Epigenome Goes Drunk: Alcohol Consumption Alters Histone Acetylation and Transcriptome

Trends Biochem Sci. 2020 Feb;45(2):93-95. doi: 10.1016/j.tibs.2019.11.002. Epub 2019 Nov 22.

Authors

Irene de Diego¹, Annika Müller-Eigner¹, Shahaf Peleg²

Affiliations

¹ Epigenetics, Metabolism, and Longevity, Independent Research Group, Leibniz Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany.
² Epigenetics, Metabolism, and Longevity, Independent Research Group, Leibniz Institute for Farm Animal Biology (FBN), 18196, Dummerstorf, Germany; Laboratory for Metabolism and Epigenetics in Brain Aging, Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, China. Electronic address: shahafpeleg3@googlemail.com.

PMID: 31767183
DOI: 10.1016/j.tibs.2019.11.002

Abstract

Recent studies demonstrated that alcohol consumption can induce epigenetic changes in the brain, although the exact mechanism underlying such changes remained unclear. Now, a report by Mews et al. shows a direct link between alcohol consumption and histone acetylation changes in the brain, which are mediated by the neuronal acetyl-CoA synthase, ACSS2.

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MeSH terms

Acetyl Coenzyme A / metabolism
Acetylation
Alcohol Drinking / genetics
Brain / metabolism
Epigenome*
Histones* / metabolism
Transcriptome

Substances

Histones
Acetyl Coenzyme A