Abstract
Children with ataxia telangiectasia have a high probability of developing acute lymphoblastic leukaemia, and have increased sensitivity to chemotherapy and irradiation. We report a 51/2 year old boy who had undiagnosed ataxia telangiectasia when he presented with acute lymphoblastic leukaemia. He subsequently developed a chemoradiation induced leukoencephalopathy after conventional central nervous system prophylaxis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Ataxia Telangiectasia / complications*
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Ataxia Telangiectasia / diagnosis
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Brain / radiation effects
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Brain Diseases / etiology*
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Brain Neoplasms / prevention & control
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Child, Preschool
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Humans
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Male
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Methotrexate / adverse effects*
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Methotrexate / therapeutic use
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
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Radiotherapy / adverse effects*