A once-a-month oral contraceptive

Ameya R Kirtane; Tiffany Hua; Alison Hayward; Ambika Bajpayee; Aniket Wahane; Aaron Lopes; Taylor Bensel; Lihong Ma; Frank Z Stanczyk; Sierra Brooks; Declan Gwynne; Jacob Wainer; Joy Collins; Siddartha M Tamang; Robert Langer; Giovanni Traverso

doi:10.1126/scitranslmed.aay2602

A once-a-month oral contraceptive

Sci Transl Med. 2019 Dec 4;11(521):eaay2602. doi: 10.1126/scitranslmed.aay2602.

Authors

Ameya R Kirtane^{1

2}, Tiffany Hua^{1

2}, Alison Hayward^{1

2

3}, Ambika Bajpayee⁴, Aniket Wahane^{1

2}, Aaron Lopes^{1

2}, Taylor Bensel^{1

2}, Lihong Ma⁵, Frank Z Stanczyk⁵, Sierra Brooks¹, Declan Gwynne^{1

2}, Jacob Wainer^{1

2}, Joy Collins^{1

2}, Siddartha M Tamang^{1

2}, Robert Langer^{6

2

7

8

9}, Giovanni Traverso^{10

11}

Affiliations

¹ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³ Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴ Departments of Bioengineering and Mechanical Engineering, Northeastern University, Boston, MA 02115, USA.
⁵ Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
⁶ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu.
⁷ Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁸ Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁹ Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
¹⁰ Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu.
¹¹ Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

PMID: 31801885
DOI: 10.1126/scitranslmed.aay2602

Abstract

Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Animals
Contraceptives, Oral / administration & dosage*
Contraceptives, Oral / blood
Contraceptives, Oral / pharmacokinetics
Dosage Forms
Drug Administration Schedule
Drug Liberation
Female
Levonorgestrel / administration & dosage
Levonorgestrel / blood
Levonorgestrel / pharmacokinetics
Swine

Substances

Contraceptives, Oral
Dosage Forms
Levonorgestrel