Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor

Annette Leibetseder; Judith Wagner; Josef Tomasits; Hans-Peter Haring; Markus Hutterer; Johannes Trenkler; Tim J von Oertzen

doi:10.3389/fneur.2019.01257

Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor

Front Neurol. 2019 Nov 26:10:1257. doi: 10.3389/fneur.2019.01257. eCollection 2019.

Authors

Annette Leibetseder¹, Judith Wagner¹, Josef Tomasits², Hans-Peter Haring¹, Markus Hutterer¹, Johannes Trenkler³, Tim J von Oertzen¹

Affiliations

¹ Department of Neurology 1, Kepler University Hospital, Medical Faculty of the Johannes Kepler University Linz, Linz, Austria.
² Institute for Clinical Pathology, Kepler University Hospital, Medical Faculty of the Johannes Kepler University Linz, Linz, Austria.
³ Institute of Neuroradiology, Kepler University Hospital, Medical Faculty of the Johannes Kepler University Linz, Linz, Austria.

Abstract

We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the SLC6A4 gene coding for the human serotonin transporter (SERT). Pathophysiological and clinical implications of these findings are discussed.

Keywords: SNRI; SSRI; delta storage pool disease; intracerebral hemorrhage; stroke; thrombocytopathy.

Publication types

Case Reports