Long-term Outcome of Patients With Nonoperated Prosthetic Valve Infective Endocarditis: Is Relapse the Main Issue?

Raphaël Lecomte; Jean-Baptiste Laine; Nahéma Issa; Matthieu Revest; Benjamin Gaborit; Paul Le Turnier; Colin Deschanvres; François Benezit; Nathalie Asseray; Thierry Le Tourneau; Sabine Pattier; Ousama Al Habash; François Raffi; David Boutoille; Fabrice Camou

doi:10.1093/cid/ciz1177

Long-term Outcome of Patients With Nonoperated Prosthetic Valve Infective Endocarditis: Is Relapse the Main Issue?

Clin Infect Dis. 2020 Aug 22;71(5):1316-1319. doi: 10.1093/cid/ciz1177.

Authors

Raphaël Lecomte^{1

2}, Jean-Baptiste Laine^{1

2}, Nahéma Issa³, Matthieu Revest^{4

5}, Benjamin Gaborit^{1

2}, Paul Le Turnier^{1

2}, Colin Deschanvres^{1

2}, François Benezit⁴, Nathalie Asseray^{1

2}, Thierry Le Tourneau⁶, Sabine Pattier⁶, Ousama Al Habash⁷, François Raffi^{1

2}, David Boutoille^{1

2}, Fabrice Camou³

Affiliations

¹ Department of Infectious Disease, University Hospital, Nantes, France.
² Centre d'Investigation Clinique Unité d'Investigation Clinique 1413 INSERM, University Hospital, Nantes, France.
³ Intensive Care and Infectious Disease Unit, Groupe Saint-André, University Hospital, Bordeaux, France.
⁴ Infectious Diseases and Intensive Care Unit, Rennes University Hospital, Rennes, France.
⁵ University of Rennes, Centre d'Investigation Clinique 1414, INSERM, Bacterial Regulatory RNAS and Medicine, Unité Mixte de Recherche 1230, Rennes, France.
⁶ Department of Cardiology, Institut du Thorax, University Hospital, Nantes, France.
⁷ Department of Thoracic and Cardiovascular Surgery, Institut du Thorax, University Hospital, Nantes, France.

PMID: 31858123
DOI: 10.1093/cid/ciz1177

Abstract

In nonoperated prosthetic valve endocarditis (PVE), long-term outcome is largely unknown. We report the follow-up of 129 nonoperated patients with PVE alive at discharge. At 1 year, the mortality rate was 24%; relapses and reinfection were rare (5% each). Enterococcal PVE was associated with a higher risk of relapse.

Keywords: infective endocarditis; prosthetic valve; relapse; surgery.

MeSH terms

Endocarditis* / epidemiology
Endocarditis, Bacterial* / drug therapy
Endocarditis, Bacterial* / epidemiology
Heart Valve Prosthesis* / adverse effects
Humans
Prosthesis-Related Infections* / epidemiology
Recurrence