Regulation of CHK1 by the Ubiquitin-Proteasome System

Maëlle Cartel; Christine Didier

doi:10.1111/febs.15173

Regulation of CHK1 by the Ubiquitin-Proteasome System

FEBS J. 2020 May;287(10):1982-1984. doi: 10.1111/febs.15173. Epub 2020 Jan 6.

Authors

Maëlle Cartel^{1

2}, Christine Didier^{1

2}

Affiliations

¹ Cancer Research Center of Toulouse, INSERM U1037, CNRS ERL 5294, Université de Toulouse, France.
² Équipe Labellisée 2016, Ligue Nationale Contre le Cancer, Toulouse, France.

PMID: 31904911
DOI: 10.1111/febs.15173

Abstract

The checkpoint kinase 1 (CHK1) is a master regulator of genome integrity in vertebrate cells. Despite its important cell cycle functions, its regulation is still incompletely understood. Cassidy et al. provide novel insights on the regulation of the CHK1 abundance by the HECT E3 ligase HUWE1 during unperturbed cell cycle as well as in response to replicative stress. These results may help us to apprehend the underlying mechanism of tumorigenesis.

Keywords: CHK1; proteasome system; ubiquitin.

Publication types

Comment

MeSH terms

Checkpoint Kinase 1 / genetics
Proteasome Endopeptidase Complex* / metabolism
Protein Stability
Ubiquitin*
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism

Substances

Ubiquitin
Ubiquitin-Protein Ligases
Checkpoint Kinase 1
Proteasome Endopeptidase Complex