Abstract
Interaction between humans and the gut microbiota is important for human physiology. Here, the gut microbiota was analyzed via metagenomic sequencing, and the fluctuations in the gut microbiota under the conditions of spaceflight were characterized. The composition and function of the gut microbiota were substantially affected by spaceflight; however, individual specificity was uncompromised. We further confirmed the species fluctuations and functional genes from both missions. Resistance and virulence genes in the gut microbiota were affected by spaceflight, but the species attributions remained stable. Spaceflight markedly affected the composition and function of the human gut microbiota, implying that the human gut microbiota is sensitive to spaceflight.
Keywords:
Gut microbiota; resistance genes; spaceflight; species composition; virulence genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacteria / classification
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Bacteria / drug effects
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Bacteria / genetics
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Bacteria / growth & development*
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Bacteroides / genetics
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Bacteroides / growth & development
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Drug Resistance, Bacterial / genetics
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Feces / microbiology
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Firmicutes / genetics
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Firmicutes / growth & development
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Gastrointestinal Microbiome*
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Gastrointestinal Tract / microbiology*
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Genes, Bacterial
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Humans
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Interspersed Repetitive Sequences
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Metagenome
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Space Flight*
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Virulence / genetics
Grants and funding
This study was supported by National Natural Science Foundation of China Project (31630038, 81830061, 31821091, 81822026, 91740114), Advanced Space Medico-engineering Research Project of China (2017SY540503), State Key Lab of Space Medicine Fundamentals and Application grants (SMFA17B03) and 1226 project (No. AWS16J018), the Key Program of Logistics Research (Grant No. BWS17J030).