Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition

Drug Metab Pharmacokinet. 2020 Feb;35(1):45-55. doi: 10.1016/j.dmpk.2019.11.001. Epub 2019 Dec 24.

Authors

Yumi Nishiya¹, Eiko Suzuki², Tomoko Ishizuka³, Miho Kazui², Hidetaka Sakurai⁴, Daisuke Nakai⁵

Affiliations

¹ Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan. Electronic address: nishiya.yumi.m4@daiichisankyo.co.jp.
² Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
³ Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
⁴ General Administration Department, Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
⁵ Biomarker & Translational Research Department, Daiichi Sankyo Co., Ltd, Tokyo, Japan.

PMID: 31926835
DOI: 10.1016/j.dmpk.2019.11.001

No abstract available

Publication types

Review

MeSH terms

Alcohol Dehydrogenase / metabolism*
Animals
Carbapenems / chemistry
Carbapenems / metabolism
Carboxylic Ester Hydrolases / metabolism*
Drug Interactions
Humans
Hydrolases / metabolism*
Peptide Hydrolases / metabolism*
Phosphatidate Phosphatase / metabolism*
Prasugrel Hydrochloride / chemistry
Prasugrel Hydrochloride / metabolism
Prodrugs / chemistry
Prodrugs / metabolism*
Pyrrolidinones / chemistry
Pyrrolidinones / metabolism
Quinolines / chemistry
Quinolines / metabolism
Valproic Acid / chemistry
Valproic Acid / metabolism

Substances

ARQ 197
Carbapenems
Prodrugs
Pyrrolidinones
Quinolines
Valproic Acid
Alcohol Dehydrogenase
Hydrolases
Carboxylic Ester Hydrolases
carboxymethylenebutenolidase
Phosphatidate Phosphatase
Peptide Hydrolases
acylaminoacyl-peptidase
Prasugrel Hydrochloride