[Progress and prospects of clinical cell therapy for liver cirrhosis and liver cancer]

Zhonghua Gan Zang Bing Za Zhi. 2019 Nov 20;27(11):822-826. doi: 10.3760/cma.j.issn.1007-3418.2019.11.002.
[Article in Chinese]

Abstract

The treatment options for liver cancer and liver cirrhosis are limited. Cell therapy (immune cells, stem cells) can significantly improve the therapeutic effect by actively regulating body's immunity. In addition, when choosing different methods of cell therapy, clinicians should also fully consider the adverse reactions associated with cell therapy. This article reviews the progress of cells therapy in clinical trials of liver cancer and liver cirrhosis, including therapeutic mechanism, advantages, disadvantages and limitations.

肝癌及肝硬化治疗选择有限。细胞治疗(免疫细胞、干细胞)通过主动地调节机体免疫可以明显提高治疗效果。同时,在选择不同的细胞治疗方式时,临床医生也应充分考虑细胞治疗所伴发的不良反应。现就细胞治疗在肝癌与肝硬化的临床试验研究中的进展,包括治疗机制、优缺点及限制性等进行综述。.

Keywords: Cell therapy; Liver cancer; Liver cirrhosis; Mesenchymal stem cells.

Publication types

  • Review

MeSH terms

  • Cell- and Tissue-Based Therapy*
  • Humans
  • Liver Cirrhosis / pathology
  • Liver Cirrhosis / therapy*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / therapy*
  • Mesenchymal Stem Cell Transplantation*
  • Mesenchymal Stem Cells / physiology*