Molty-Level Regulation: Lysosomes Participate in Developmental ECM Remodeling in C. elegans

Soudabeh Imanikia; Rebecca C Taylor

doi:10.1016/j.devcel.2019.12.008

Molty-Level Regulation: Lysosomes Participate in Developmental ECM Remodeling in C. elegans

Dev Cell. 2020 Jan 6;52(1):1-2. doi: 10.1016/j.devcel.2019.12.008.

Authors

Soudabeh Imanikia¹, Rebecca C Taylor²

Affiliations

¹ Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
² Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: rtaylor@mrc-lmb.cam.ac.uk.

PMID: 31951553
DOI: 10.1016/j.devcel.2019.12.008

Abstract

Dynamic regulation of lysosomes allows them to play key roles in cell and tissue homeostasis. In this issue of Developmental Cell, Miao et al. find that a novel transcriptional pathway triggered by loss of cell adhesion activates lysosomes in C. elegans epidermis during developmental remodeling of the cuticle.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans Proteins*
Caenorhabditis elegans*
Cell Nucleus
Lysosomes
Signal Transduction

Substances

Caenorhabditis elegans Proteins