Inhibiting inflammation is helpful in relieving the absorption of alveolar bone and promoting periodontal bone regeneration. In a previous study, we showed that transforming growth factor-beta1 (TGF-β1)-induced Treg cells inhibit the absorption of tissue-engineered cartilage caused by endogenous IFN-γ and TNF-α. In this study, we investigated the effect of inhibiting local inflammatory responses on Geistlich Bio-Oss® osteogenesis promotion in vivo. TGF-β1+BMMSCs (bone marrow mesenchymal stem cells) were cultured in Geistlich Bio-Oss® medium, and biocompatibility was evaluated. Alveolar bone defects in New Zealand rabbits repaired by application of Geistlich Bio-Oss® were compared to the effects of added TGF-β1+BMMSCs. There was no significant difference between the untreated Geistlich Bio-Oss® medium-control group and the group treated with the addition of TGF-β1+BMMSCs. Pro-inflammatory cytokines IFN-γ and TNF-α delayed Geistlich Bio-Oss®-induced osteogenesis, but no significant difference in osteogenesis was seen with the addition of TGF-β1+BMMSCs. Geistlich Bio-Oss® has good compatibility with TGF-β1+BMMSCs. However, the dual role of in vivo TGF-β1+BMMSCs in regenerating periodontal bone and limiting local inflammation is not clear.
Keywords: Geistlich Bio-Oss®; Transforming growth factor-beta1; interferon-γ; tumor necrosis factor-α.
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