Backgrounds: We aimed to evaluate the association of SNPs in GCKR, MTNR1B, KCNQ1, and KLF14 genes confirmed in previous studies and hapertriglyceridemic waist (HTGW) in Han Chinese, and assess the interactions between genes and behavior risk factors.
Methods: We genotyped the single nucleotide polymorphisms (SNPs) for GCKR, MTNR1B, KCNQ1, and KLF14 gene were genotyped in 373 patients with HTGW and 466 normal healthy subjects. We used logistic regression to investigate the gene-gene, gene-behavior interactions for the risk of HTGW.
Results: Among the 4 SNPs, the AG genotype of rs780094 was protective factor, whereas the recessive model of rs151290 was risk factor after adjusting for confounders. Stratified by sex, only for women, the recessive model of rs151290 was still significance. The significant synergies interactions between SNPs were found between rs780094 in GCKR and rs972283 in KLF14 and rs10830963 in MTNR1B, respectively; meanwhile, the antagonistic interaction was revealed for rs151290 and rs780094 only for women. For male, there were significant synergies interactions between rs780094, smoking and alcohol drinking; and antagonistic interaction was revealed between rs780094 and severe activity both for men and women.
Conclusions: GCKR and KLF14 genes play a significant role in risk of HTGW in a Han Chinese population.
Keywords: Chinese; HTGW; Polymorphisms; interaction.
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