KPC-producing Enterobacterales with uncommon carbapenem susceptibility profile in Vitek 2 system

Int J Infect Dis. 2020 Apr:93:118-120. doi: 10.1016/j.ijid.2020.01.016. Epub 2020 Jan 21.

Abstract

KPC-producing K. pneumoniae is an endemic challenge. Seven KPC-producing Enterobacterales showed unusual carbapenems susceptibility profile. These strains were resistance at least one carbapenem and the ertapenem MIC was lower than imipenem and/or meropenem MICs using Vitek 2™ system (bioMerieux). When E-test™ and disk diffusion methods were performed the carbapenems showed susceptible results.

Keywords: Carbapenemases; Carbapenems; Enterobacterales; KPC; Vitek 2™ system.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / biosynthesis*
  • Carbapenems / pharmacology*
  • Drug Resistance, Bacterial
  • Ertapenem / pharmacology
  • Gammaproteobacteria / drug effects*
  • Imipenem / pharmacology
  • Klebsiella pneumoniae / enzymology
  • Meropenem / pharmacology
  • Microbial Sensitivity Tests
  • beta-Lactamases / biosynthesis*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • Imipenem
  • beta-Lactamases
  • carbapenemase
  • Meropenem
  • Ertapenem