SEOM clinical guideline on hereditary colorectal cancer (2019)

Clin Transl Oncol. 2020 Feb;22(2):201-212. doi: 10.1007/s12094-019-02272-y. Epub 2020 Jan 24.

Abstract

In the last 2 decades, clinical genetics on hereditary colorectal syndromes has shifted from just a molecular characterization of the different syndromes to the estimation of the individual risk of cancer and appropriate risk reduction strategies. In the last years, new specific therapies for some subgroups of patients have emerged as very effective alternatives. At the same time, germline multigene panel testing by next-generation sequencing (NGS) technology has become the new gold standard for molecular genetics.

Keywords: Adenomatous polyposis; Colon cancer; Hereditary colorectal cancer; Lynch syndrome.

MeSH terms

  • Clinical Trials as Topic / standards*
  • Colorectal Neoplasms / genetics
  • Colorectal Neoplasms / prevention & control*
  • Genetic Predisposition to Disease*
  • Humans
  • Medical Oncology
  • Mutation*
  • Neoplasm Proteins / genetics*
  • Practice Guidelines as Topic / standards*
  • Societies, Medical

Substances

  • Neoplasm Proteins