Severe fingolimod rebound syndrome after switching to cladribine treatment

Mult Scler Relat Disord. 2020 May:40:101938. doi: 10.1016/j.msard.2020.101938. Epub 2020 Jan 16.

Abstract

We present the clinical and imaging characteristics of a patient whom presented with rebound syndrome after switching from fingolimod to cladribine treatment due to hematologic toxicity. Previous imaging studies had shown a non-aggressive phenotype of the disease, however multiple active tumefactive lesions became evident after beginning treatment with cladribine. The patient responded well to plasmapheresis.

Keywords: Cladribine; Fingolimod; Multiple sclerosis; Rebound.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cladribine / administration & dosage*
  • Female
  • Fingolimod Hydrochloride / adverse effects
  • Fingolimod Hydrochloride / pharmacology*
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / pharmacology*
  • Magnetic Resonance Imaging
  • Multiple Sclerosis, Relapsing-Remitting / diagnostic imaging
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Multiple Sclerosis, Relapsing-Remitting / immunology
  • Recurrence

Substances

  • Immunosuppressive Agents
  • Cladribine
  • Fingolimod Hydrochloride