Dendritic cell development: A personal historical perspective

Mol Immunol. 2020 Mar:119:64-68. doi: 10.1016/j.molimm.2019.12.016. Epub 2020 Jan 24.

Abstract

Dendritic cells(DCs) were once considered as a single cell type closely related developmentally to macrophages. Now we recognise several subtypes of DCs and have outlined several different pathways that potentially lead to their development. This article outlines some of the research findings that led to these changes in perspective, from the point of view of one of the participants.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Bone Marrow Cells / physiology
  • Cell Biology / history*
  • Cell Differentiation / physiology
  • Cytokines / physiology
  • Dendritic Cells / physiology*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Thymus Gland / cytology

Substances

  • Cytokines