Disease escape with the selective loss of the Philadelphia chromosome after tyrosine kinase inhibitor exposure in Ph-positive acute lymphoblastic leukemia

Leukemia. 2020 Aug;34(8):2230-2233. doi: 10.1038/s41375-020-0715-2. Epub 2020 Jan 27.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Female
  • Fusion Proteins, bcr-abl / genetics
  • Fusion Proteins, bcr-abl / physiology
  • Humans
  • Middle Aged
  • Philadelphia Chromosome*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Protein Kinase Inhibitors / therapeutic use*

Substances

  • BCR-ABL1 fusion protein, human
  • Protein Kinase Inhibitors
  • Fusion Proteins, bcr-abl