Playing Favorites: Integrin αvβ5 Mediates Preferential Zika Infection of Neural Stem Cells

Christine Vazquez; Kellie Ann Jurado

doi:10.1016/j.stem.2020.01.007

Playing Favorites: Integrin αvβ5 Mediates Preferential Zika Infection of Neural Stem Cells

Cell Stem Cell. 2020 Feb 6;26(2):133-135. doi: 10.1016/j.stem.2020.01.007.

Authors

Christine Vazquez¹, Kellie Ann Jurado²

Affiliations

¹ Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: kellie.jurado@pennmedicine.upenn.edu.

PMID: 32032522
DOI: 10.1016/j.stem.2020.01.007

Abstract

The molecular basis dictating specificity of Zika virus infection in neural stem cells (NSCs) remains elusive. Two recent papers in Cell Stem Cell (Zhu et al., 2020) and Cell Reports (Wang et al., 2020) identify integrin αvβ5 as an internalization factor that increases susceptibility in NSCs and glioblastoma stem cells.

Publication types

Comment

MeSH terms

Glioblastoma*
Humans
Neural Stem Cells*
Receptors, Vitronectin
SOXB1 Transcription Factors
Zika Virus Infection*
Zika Virus*

Substances

Receptors, Vitronectin
SOX2 protein, human
SOXB1 Transcription Factors
integrin alphaVbeta5