Management of children and adolescents with gray zone lymphoma: A case series

Pediatr Blood Cancer. 2020 May;67(5):e28206. doi: 10.1002/pbc.28206. Epub 2020 Feb 9.

Abstract

Background: Data on management of gray zone lymphoma (GZL) in children and adolescents are scarce.

Procedure: This retrospective study assessed clinical characteristics and outcome in six Austrian patients with GZL less than 18 years of age (male-to-female ratio: 1:1; median age: 15.8 years).

Results: Two patients each had a classical Hodgkin lymphoma (cHL)-like and composite GZL subtype, and one patient each had a large B-cell non-Hodgkin lymphoma (LBCL)-like and sequential GZL subtype. All had advanced disease with mediastinal and extranodal involvement. Five patients received an LBCL- and one patient a cHL-directed polychemotherapy ± radiotherapy. Out of the former patients, three survived, including two who relapsed and underwent high-dose chemotherapy with autologous stem cell rescue. The latter patient survived.

Conclusions: GZL remains a diagnostic and therapeutic challenge, necessitating the development of novel treatment concepts performed in a prospective setting.

Keywords: checkpoint inhibitors; gray zone lymphoma; outcome; relapse; treatment.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Austria
  • Autografts
  • Chemoradiotherapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / diagnosis
  • Lymphoma, Large B-Cell, Diffuse / therapy*
  • Male
  • Mediastinal Neoplasms / diagnosis
  • Mediastinal Neoplasms / therapy*
  • Retrospective Studies
  • Stem Cell Transplantation*